The in vivo effects of puromycin on amylase levels in the serum, liver, salivary glands, and pancreas of the rat

When puromycin is administered in multiple doses to rats over a period of several hours, both serum and liver amylase levels are lowered to about 50% of the control values. Amylase levels of the parotid and submaxillary glands are not changed significantly by such treatment. The amylase level of the...

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Bibliographic Details
Published inArchives of biochemistry and biophysics Vol. 107; no. 3; pp. 534 - 536
Main Authors McGeachin, Robert L., Johnson, Wallace D.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.09.1964
Subjects
Amylases
Liver
Old Medline
Pancreas
Pharmacology
Puromycin
Rats
Salivary Glands
PUROMYCIN
PHARMACOLOGY
AMYLASE
EXPERIMENTAL LAB STUDY
LIVER
PANCREAS
RATS
SALIVARY GLANDS
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Summary:When puromycin is administered in multiple doses to rats over a period of several hours, both serum and liver amylase levels are lowered to about 50% of the control values. Amylase levels of the parotid and submaxillary glands are not changed significantly by such treatment. The amylase level of the pancreas is lowered by 25%, but such lowering is only of borderline significance. If puromycin is given in single doses, its effects are transient. These data on the effect of puromycin in vivo indicate that the liver may be the principal source of serum amylase and that the contributions of the salivary glands and the pancreas to serum amylase are relatively small.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0003-9861
1096-0384
DOI:10.1016/0003-9861(64)90312-1