DCC and netrins

Recent advances highlight the versatility and complexity of this highly conserved axon and cell migration guidance system. Characterization of netrin mutant phenotypes in worm, fly and mouse all suggest that netrins play local as well as long-range roles in guidance. Evidence from multiple sources a...

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Bibliographic Details
Published inCurrent opinion in cell biology Vol. 10; no. 5; pp. 609 - 613
Main Authors Culotti, Joseph G, Merz, David C
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.10.1998
Subjects
Caenorhabditis elegans Proteins
Cell Adhesion Molecules
Cell Movement - physiology
Growth Cones - physiology
Nerve Growth Factors
Nervous System - growth & development
Receptors, Nerve Growth Factor
Ig immunoglobulin
CNS central nervous system
RGC retinal ganglion cell
Fra Frazzled
PKA protein kinase A
DCC deleted in colorectal cancer
PVT posterior ventral T neuron
BDNF brain-derived neutrophic factor
RP3 Drosophila embryonic motorneuron
PVP posterior ventral P neuron
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Summary:Recent advances highlight the versatility and complexity of this highly conserved axon and cell migration guidance system. Characterization of netrin mutant phenotypes in worm, fly and mouse all suggest that netrins play local as well as long-range roles in guidance. Evidence from multiple sources also indicates that the netrin receptor DCC can mediate both attractive and repulsive responses to netrins.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0955-0674
1879-0410
DOI:10.1016/S0955-0674(98)80036-7