Immunoglobulins in infants of rubella-exposed mothers

Noninfected infants of women who received large doses of gamma globulin early in pregnancy for the prevention of rubella were found to have lower serum IgG levels than normal controls up until 1 year of age. This effect, however, did not create clinical problems. Infected babies, as defined by the p...

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Bibliographic Details
Published inThe Journal of pediatrics Vol. 75; no. 6; pp. 1186 - 1193
Main Authors Huntley, Carolyn C., Lyerly, Anne D., Patterson, Miriam V., Sever, John L.
Format Journal Article
LanguageEnglish
Published United States Mosby, Inc 01.12.1969
Subjects
Child, Preschool
Female
gamma-Globulins - adverse effects
gamma-Globulins - therapeutic use
Humans
Immunity, Maternally-Acquired
Immunoglobulin G
Immunoglobulin M
Infant
Infant, Newborn
Infant, Newborn, Diseases
Pregnancy
Pregnancy Complications, Infectious
Rubella - immunology
Rubella - prevention & control
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Summary:Noninfected infants of women who received large doses of gamma globulin early in pregnancy for the prevention of rubella were found to have lower serum IgG levels than normal controls up until 1 year of age. This effect, however, did not create clinical problems. Infected babies, as defined by the presence of rubella antibody persisting beyond 5 months of age, had higher serum IgM and IgG concentrations than noninfected babies until age 2 years.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-3476
1097-6833
DOI:10.1016/S0022-3476(69)80374-4