Synthesis of 3-Substituted 1,4-Benzodiazepin-2-ones
The preparation of 3-substituted 1,4-benzodiazepines by benzodiazepine enolate alkylation has been explored. Employing this approach, multigram quantities of benzodiazepine 1 have been prepared for animal studies to evaluate a new approach for the treatment of the autoimmune disease systemic lupus e...
Saved in:
Published in | Journal of the Brazilian Chemical Society Vol. 9; no. 4; pp. 375 - 379 |
---|---|
Main Authors | , , |
Format | Journal Article |
Language | English Portuguese |
Published |
Sociedade Brasileira de Química
01.08.1998
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | The preparation of 3-substituted 1,4-benzodiazepines by benzodiazepine enolate alkylation has been explored. Employing this approach, multigram quantities of benzodiazepine 1 have been prepared for animal studies to evaluate a new approach for the treatment of the autoimmune disease systemic lupus erythematosus (SLE). |
---|---|
ISSN: | 0103-5053 1678-4790 0103-5053 |
DOI: | 10.1590/S0103-50531998000400010 |