Synthesis of 3-Substituted 1,4-Benzodiazepin-2-ones

The preparation of 3-substituted 1,4-benzodiazepines by benzodiazepine enolate alkylation has been explored. Employing this approach, multigram quantities of benzodiazepine 1 have been prepared for animal studies to evaluate a new approach for the treatment of the autoimmune disease systemic lupus e...

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Bibliographic Details
Published inJournal of the Brazilian Chemical Society Vol. 9; no. 4; pp. 375 - 379
Main Authors Kyungjin, Kim, Volkman, Steven K., Ellman, Jonathan A.
Format Journal Article
LanguageEnglish
Portuguese
Published Sociedade Brasileira de Química 01.08.1998
Subjects
benzodiazepine enolate-alkylation
CHEMISTRY, MULTIDISCIPLINARY
systemic lupus erythematosus
benzodiazepine enolate-alkylation
systemic lupus erythematosus
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Summary:The preparation of 3-substituted 1,4-benzodiazepines by benzodiazepine enolate alkylation has been explored. Employing this approach, multigram quantities of benzodiazepine 1 have been prepared for animal studies to evaluate a new approach for the treatment of the autoimmune disease systemic lupus erythematosus (SLE).
ISSN:0103-5053
1678-4790
0103-5053
DOI:10.1590/S0103-50531998000400010