The ultrastructural heterogeneity of potentially preneoplastic lesions in the human bronchial mucosa

170 consecutive biopsies from the bronchial tree were subjected to ultrastructural analysis. 62 were identified as preneoplastic lesions: of these, 7 as goblet cell hyperplasia, 20 as basal cell hyperplasia, 17 as combined goblet and basal cell hyperplasia, 10 as epidermoid metaplasia, and 8 as dysp...

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Bibliographic Details
Published inPathology, research and practice Vol. 181; no. 4; p. 408
Main Authors Gonzalez, S, von Bassewitz, D B, Grundmann, E, Nakhosteen, J A, Müller, K M
Format Journal Article
LanguageEnglish
Published Germany 01.08.1986
Subjects
Adult
Aged
Aged, 80 and over
Bronchial Neoplasms - pathology
Bronchial Neoplasms - ultrastructure
Carcinoma - pathology
Carcinoma - ultrastructure
Cell Transformation, Neoplastic
Female
Humans
Hyperplasia
Male
Microscopy, Electron
Middle Aged
Precancerous Conditions - pathology
Precancerous Conditions - ultrastructure
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Summary:170 consecutive biopsies from the bronchial tree were subjected to ultrastructural analysis. 62 were identified as preneoplastic lesions: of these, 7 as goblet cell hyperplasia, 20 as basal cell hyperplasia, 17 as combined goblet and basal cell hyperplasia, 10 as epidermoid metaplasia, and 8 as dysplasia. The ultrastructural features of these lesions are described. According to these results, preneoplastic lesions of the human bronchial mucosa are composed of heterogeneous populations that display mixed or combined morphologic features signaling abnormal differentiation patterns at this stage. The findings are tentatively correlated with bronchial carcinoma cell heterogeneity and histogenesis.
ISSN:0344-0338
1618-0631
DOI:10.1016/S0344-0338(86)80076-0