An analysis of the variation of plasma concentrations of placental protein 14 in artificial cycles

• Published in: Fertility and sterility Vol. 57; no. 4; pp. 776 - 782
• Main Authors: Li, Tin-Chiu, Dalton, Caroline, Bolton, Anthony E., Ling, Elizabeth, Warren, Alistair, Cooke, Ian D.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.1992
• Subjects: Adult; artificial cycles; Estradiol - blood; Estradiol - therapeutic use; Estrogen Replacement Therapy; Female; Follicle Stimulating Hormone - blood; Glycodelin; Glycoproteins; Humans; Menstrual Cycle - blood; Menstrual Cycle - drug effects; Placental protein; Pregnancy Proteins - blood; Primary Ovarian Insufficiency - blood; Primary Ovarian Insufficiency - drug therapy; Primary Ovarian Insufficiency - physiopathology; Progesterone - blood; Reference Values; Turner Syndrome - blood; Turner Syndrome - drug therapy; Turner Syndrome - physiopathology; Placental protein; artificial cycles
• ISSN: 0015-0282; 1556-5653
• DOI: 10.1016/S0015-0282(16)54958-9

To analyze the factors affecting the variation of plasma concentration of placental protein 14 (PP14) in artificial cycles. The effects of different hormone replacement therapy (HRT) regimens were examined in a crossover design. Jessop Hospital for Women, Sheffield, United Kingdom. Eighteen women with premature ovarian failure: 6 associated with Turner’s syndrome and 12 with idiopathic premature ovarian failure. Four different HRT regimens; 36 study cycles. Plasma PP14 concentrations on days 1, 15, 19, and 29 of the artificial cycles. In cycles treated with a standard HRT, the levels were similar to those of the natural cycle. Subjects with Turner’s syndrome did not have elevated PP14 levels, whereas the majority 91275% of those with idiopathic premature ovarian failure had elevated levels on day 29 of the cycle. Levels of PP14 were reduced when either the doses of estradiol valerate were reduced to 13 or the doses of progesterone (P) were reduced to 15 of the standard HRT. Plasma levels of PP14 are dependent not only on P stimulation but also on adequate estrogen priming.