Effects of cyclosporine in recent-onset juvenile type 1 diabetes: Impact of age and duration of disease

Administration of cyclosporine resulted in reduced insulin requirements andimproved glycemic control in patients with insulin-dependent diabetes mellitus of recent onset, but the drug was less effective in young children. Renal toxic effects and other problems related to therapy resolved after disco...

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Published inThe Journal of pediatrics Vol. 111; no. 6; pp. 1069 - 1072
Main Authors Stiller, C.R., Dupre, J., Gent, M., Heinrichs, D., Jenner, M.R., Keown, P.A., Laupacis, A., Martell, R., Rodger, N.W., Wolfe, B.M.J., Mahon, J.
Format Journal Article
LanguageEnglish
Published United States Mosby, Inc 01.12.1987
Subjects
Adolescent
Adult
Age Factors
Autoantibodies - analysis
Autoimmune Diseases - drug therapy
Child
Child, Preschool
Cyclosporins - adverse effects
Cyclosporins - therapeutic use
Diabetes Mellitus, Type 1 - drug therapy
Drug Evaluation
Glucose Tolerance Test
Humans
Infant
Insulin - administration & dosage
Islets of Langerhans - immunology
Kidney Diseases - chemically induced
Middle Aged
Time Factors
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Summary:Administration of cyclosporine resulted in reduced insulin requirements andimproved glycemic control in patients with insulin-dependent diabetes mellitus of recent onset, but the drug was less effective in young children. Renal toxic effects and other problems related to therapy resolved after discontinuation of the drug. Sustained remission seemed dependent on continued administration of cyclosporine. Although short-term control of diabetes may be achieved in some patients, more studies are needed to determine whether cyclosporine can be given safely as maintenance therapy to maintain glycemic control and prevent the long-term consequences of the disease.
ISSN:0022-3476
1097-6833
DOI:10.1016/S0022-3476(87)80058-6