Preparation and Characterization of PEG-PLA Genistein Micelles Using a Modified Emulsion-Evaporation Method

• Published in: Journal of nanomaterials Vol. 2020; no. 2020; pp. 1 - 15
• Main Authors: Wu, Jizhou, Li, Guojian, Yu, Yanhong, Qin, Wen, Cheng, Qiuchen, Zhuo, Lang
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2020; Hindawi; John Wiley & Sons, Inc
• Subjects: Acetone; Bioavailability; Cell cycle; Copolymers; Encapsulation; Evaporation; Experiments; Fourier transforms; Hemodialysis; Infrared analysis; Micelles; Morphology; Muscles; Nanomaterials; Nanoparticles; Polydispersity; Polyethylene glycol; Polylactic acid; Polyvinyl alcohol; Solubility; Trehalose; Beijing China; United Kingdom > UK; United States > US; China

The objective of this study is to improve the bioavailability of genistein by encapsulation with polyethylene glycol-polylactic acid (PEG-PLA) copolymers. Genistein micelles (GMs) prepared using a modified emulsion-evaporation method were more stable than those made with the original method. The eff...