The Chromatographic Separation of Mixtures of Benzodiazepine Drugs

Rapid separation of mixtures of benzodiazepine drugs was achieved using a thin-layer system based on alumina, complemented by a silica gel loaded paper system. Location of the spots was by short-wavelength ultraviolet light and acidified potassium iodoplatinate. The compounds examined were Chlordiaz...

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Bibliographic Details
Published inJournal - Forensic Science Society Vol. 11; no. 3; pp. 183 - 186
Main Authors Stevens, H.M., Jenkins, R.W.
Format Journal Article
LanguageEnglish
Published England Elsevier Ireland Ltd 01.07.1971
Subjects
Aluminum Silicates
Benzazepines - isolation & purification
Chlordiazepoxide - isolation & purification
Chromatography, Paper
Chromatography, Thin Layer
Diazepam - isolation & purification
Methods
Oxazepam - isolation & purification
Silicon Dioxide
Ultraviolet Rays
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Summary:Rapid separation of mixtures of benzodiazepine drugs was achieved using a thin-layer system based on alumina, complemented by a silica gel loaded paper system. Location of the spots was by short-wavelength ultraviolet light and acidified potassium iodoplatinate. The compounds examined were Chlordiazepoxide, Diazepam, Nitrazepam, Oxazepam, Bromazepam, Medazepam and Dibenzepine. Their behaviour to ultraviolet light of wavelength 254nm and 350nm under neutral, acid and alkaline conditions was examined in the form of spot tests on filter paper.
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SourceType-Scholarly Journals-1
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ISSN:0015-7368
DOI:10.1016/S0015-7368(71)70651-3