Severe COVID-19 after liver transplantation, surviving the pitfalls of learning on-the-go: Three case reports
The novel coronavirus 2019 (COVID-19) pandemic has dramatically transformed the care of the liver transplant patient. In patients who are immunosuppressed and with multiple comorbidities, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been associated with increased severi...
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Published in | World journal of hepatology Vol. 12; no. 10; pp. 870 - 879 |
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Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Baishideng Publishing Group Inc
27.10.2020
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Subjects | |
Online Access | Get full text |
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Summary: | The novel coronavirus 2019 (COVID-19) pandemic has dramatically transformed the care of the liver transplant patient. In patients who are immunosuppressed and with multiple comorbidities, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been associated with increased severity and mortality. The main objective of this report is to communicate our experience in the therapeutic management of SARS-CoV-2 infection in 3 liver transplant patients. Secondly, we stress the management and investigation of the contagious spreading into a liver transplant ward.
The patients were two women (aged 61 years and 62 years) and one man (aged 68 years), all of them having recently received a liver transplant. All three patients required intensive care unit admission and invasive mechanical ventilation. Two of them progressed severely until death. The other one, who received tocilizumab, had a good recovery. In the outbreak, the wife of one of the patients and four healthcare professionals involved in their care were also infected.
We illustrate in detail the evolution of a nosocomial COVID-19 outbreak in a liver transplant ward. We believe that these findings will contribute to a better understanding of the natural history of the disease and will improve the treatment of the liver transplant patient with COVID-19. |
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Bibliography: | Corresponding author: Felipe Alconchel, MD, PhD, Doctor, Surgeon, Department of Surgery and Organ Transplantation, Virgen de la Arrixaca University Hospital, Ctra. Madrid-Cartagena s/n, Murcia 30120, Spain. alconchelgago@gmail.com Author contributions: Alconchel F, Cascales-Campos PA and Ramírez P designed this article; Alconchel F, Pons JA, Martínez M, Valiente-Campos J, Martínez-Alarcón L, Ortiz ML and Gajownik U collected a substantial portion of data; Alconchel F, Cascales-Campos PA, Parrilla P, Robles R, Sánchez-Bueno F, Moreno S and Ramírez P analysised and interpreted of data; Alconchel F, Cascales-Campos PA and Ramírez P drafted of the manuscript; Parrilla P, Robles R, Sánchez-Bueno F, Moreno S and Ramírez P revised of the manuscript's important intellectual content critically; Parrilla P and Ramírez P supervised; Alconchel F, Cascales-Campos PA, Pons JA, Martínez M, Valiente-Campos J, Gajownik U, Ortiz ML, Parrila P, Robles R, Sánchez-Bueno F, Moreno S and Ramírez approved of the final version to be published. |
ISSN: | 1948-5182 1948-5182 |
DOI: | 10.4254/wjh.v12.i10.870 |