DNA-chlorpheniramine interaction studied by spectroscopic techniques
It was previously studied that the antihistaminic chlorpheniramine elicits a biphasic response on cell growth and regulates polyamine metabolism, as described for polyamines. In part, polyamine effects on macromolecular synthesis and cell growth are attributed to nucleic acid:polyamine interactions....
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| Published in | Biochimica et biophysica acta Vol. 1379; no. 1; pp. 129 - 133 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
08.01.1998
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0304-4165 0006-3002 1872-8006 |
| DOI | 10.1016/S0304-4165(97)00093-7 |
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| Abstract | It was previously studied that the antihistaminic chlorpheniramine elicits a biphasic response on cell growth and regulates polyamine metabolism, as described for polyamines. In part, polyamine effects on macromolecular synthesis and cell growth are attributed to nucleic acid:polyamine interactions. In this work, we have tested the hypothesis of a DNA:chlorpheniramine interaction, using fluorometry, FTIR and Raman spectroscopic techniques. The results indicate that DNA:chlorpheniramine interaction occurs inducing conformational changes in the macromolecule by affecting both phosphodiester bonds and bases. Results open new perspectives for characterization of action mechanisms of natural or synthetic diamines with pharmacological or physiological importance. |
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| AbstractList | It was previously studied that the antihistaminic chlorpheniramine elicits a biphasic response on cell growth and regulates polyamine metabolism, as described for polyamines. In part, polyamine effects on macromolecular synthesis and cell growth are attributed to nucleic acid:polyamine interactions. In this work, we have tested the hypothesis of a DNA:chlorpheniramine interaction, using fluorometry, FTIR and Raman spectroscopic techniques. The results indicate that DNA:chlorpheniramine interaction occurs inducing conformational changes in the macromolecule by affecting both phosphodiester bonds and bases. Results open new perspectives for characterization of action mechanisms of natural or synthetic diamines with pharmacological or physiological importance.It was previously studied that the antihistaminic chlorpheniramine elicits a biphasic response on cell growth and regulates polyamine metabolism, as described for polyamines. In part, polyamine effects on macromolecular synthesis and cell growth are attributed to nucleic acid:polyamine interactions. In this work, we have tested the hypothesis of a DNA:chlorpheniramine interaction, using fluorometry, FTIR and Raman spectroscopic techniques. The results indicate that DNA:chlorpheniramine interaction occurs inducing conformational changes in the macromolecule by affecting both phosphodiester bonds and bases. Results open new perspectives for characterization of action mechanisms of natural or synthetic diamines with pharmacological or physiological importance. It was previously studied that the antihistaminic chlorpheniramine elicits a biphasic response on cell growth and regulates polyamine metabolism, as described for polyamines. In part, polyamine effects on macromolecular synthesis and cell growth are attributed to nucleic acid:polyamine interactions. In this work, we have tested the hypothesis of a DNA:chlorpheniramine interaction, using fluorometry, FTIR and Raman spectroscopic techniques. The results indicate that DNA:chlorpheniramine interaction occurs inducing conformational changes in the macromolecule by affecting both phosphodiester bonds and bases. Results open new perspectives for characterization of action mechanisms of natural or synthetic diamines with pharmacological or physiological importance. |
| Author | Chavarrı́a, Teresa Ruiz-Chica, Joaquı́n Sánchez-Jiménez, Francisca Medina, Miguel Ángel López-Navarrete, Juan T Ramı́rez, Francisco Javier |
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| Keywords | DNA structure Chlorpheniramine Polyamine CPA, chlorpheniramine EtBr, ethidium bromide Laser Raman FTIR CT-DNA, calf-thymus DNA ODC, ornithine decarboxylase Spi, spermine |
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| SubjectTerms | Chlorpheniramine Chlorpheniramine - metabolism Chlorpheniramine - pharmacology Diamines - metabolism DNA - chemistry DNA - metabolism DNA structure Electrophoresis, Agar Gel Ethidium - metabolism Fluorometry FTIR Histamine H1 Antagonists - pharmacology Intercalating Agents - metabolism Laser Raman Nucleic Acid Conformation Plasmids - metabolism Polyamine Spectroscopy, Fourier Transform Infrared Spectrum Analysis, Raman |
| Title | DNA-chlorpheniramine interaction studied by spectroscopic techniques |
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