Quantitative and qualitative changes in intestinal goblet cells during primary infection of Trichostrongylus colubriformis high and low responder guinea pigs

Small intestine goblet cell numbers and the composition of their mucus were compared in guinea pigs with genetically determined differences in responsiveness to Trichostrongylus colubriformis infection. Prior to infection, no differences between high responder and low responder animals were detected...

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Published inInternational journal for parasitology Vol. 28; no. 5; pp. 761 - 765
Main Authors Manjili, M.H, France, M.P, Sangster, N.C, Rothwell, T.L.W
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.05.1998
Subjects
Animals
Disease Susceptibility
Feces - parasitology
Goblet cells
Guinea Pigs
Host-Parasite Interactions
Intestinal Mucosa - chemistry
Intestinal Mucosa - parasitology
Intestinal Mucosa - pathology
Mucins - analysis
Mucus
Parasite Egg Count
Staining and Labeling
Time Factors
Trichostrongylosis - immunology
Trichostrongylosis - parasitology
Trichostrongylosis - pathology
Trichostrongylus
Trichostrongylus - physiology
Mucus
Goblet cells
Trichostrongylus
Guinea pigs
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Summary:Small intestine goblet cell numbers and the composition of their mucus were compared in guinea pigs with genetically determined differences in responsiveness to Trichostrongylus colubriformis infection. Prior to infection, no differences between high responder and low responder animals were detected. However, following primary infection with T. colubriformis, pronounced goblet cell hyperplasia developed and the proportion of sulphomucin in these cells increased. Both changes developed significantly earlier in high responder animals.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0020-7519
1879-0135
DOI:10.1016/S0020-7519(98)00026-5