The long-term influence of isoproterenol (ISO) retard tablets on the course of an acute inflammation

Rats were exposed for 21 d to Isoproterenol (ISO) applied by subcutaneously implanted retard tablets. ISO causes a rise in the number of lymphocytes at the site of inflammation (injected sephadex) until the tenth day. The reaction of the connective tissue is moderately enhanced. The weight of the sa...

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Bibliographic Details
Published inExperimental pathology (1981) Vol. 25; no. 2; p. 107
Main Authors Egger, E, Korsatko, W, Porta, S
Format Journal Article
LanguageEnglish
Published Germany 1984
Subjects
Acute Disease
Animals
Body Weight - drug effects
Delayed-Action Preparations
Dextrans - toxicity
Heart - anatomy & histology
Heart - drug effects
Inflammation - chemically induced
Inflammation - drug therapy
Inflammation - physiopathology
Isoproterenol - administration & dosage
Isoproterenol - pharmacology
Leukocyte Count
Leukocytes - drug effects
Male
Organ Size - drug effects
Rats
Rats, Inbred Strains
Salivary Glands - anatomy & histology
Salivary Glands - drug effects
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Summary:Rats were exposed for 21 d to Isoproterenol (ISO) applied by subcutaneously implanted retard tablets. ISO causes a rise in the number of lymphocytes at the site of inflammation (injected sephadex) until the tenth day. The reaction of the connective tissue is moderately enhanced. The weight of the salivary glands is constantly elevated,and the weight of the hearts increases in a linear pattern until the end of the experiment. Neither in test nor in control animals is there any correlation between the number of white cells in the blood and their appearance at the site of inflammation.
ISSN:0232-1513
DOI:10.1016/S0232-1513(84)80016-X