Scurvy and anaemia

The clinical and haematologic findings in seven patients with scurvy are presented. Although all had overt scurvy, two were not anaemic. Four had hypochromic normoblastic erythropoiesis and one had a megaloblastic anaemia subsequently shown to be Addisonian, Complete haematologic remission was obtai...

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Published inThe American journal of medicine Vol. 32; no. 2; pp. 240 - 250
Main Authors Cox, E.V, Meynell, M.J, Cooke, W.T, Gaddie, R
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.02.1962
Subjects
Anemia
Humans
Old Medline
Scurvy
SCURVY
ANEMIA
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Summary:The clinical and haematologic findings in seven patients with scurvy are presented. Although all had overt scurvy, two were not anaemic. Four had hypochromic normoblastic erythropoiesis and one had a megaloblastic anaemia subsequently shown to be Addisonian, Complete haematologic remission was obtained with ascorbic acid in two patients. In two, the response to folic acid appeared to be insignificant and the complete response was attributable to ascorbic acid only. No haematologic change was produced in the patient with megaloblastic anaemia. In two patients the simultaneous occurrence of both scurvy and deficiency of vitamin B 12 did not result in a megaloblastic anaemia. Therapy with ascorbic acid resulted in reduction of the urinary excretion of folic acid-like activity, with no significant changes in the excretion of citrovorum factor. The role of ascorbic acid in erythropoiesis is discussed and a hypothesis presented to explain the therapeutic responses to this vitamin of megaloblastic anaemias in scurvy reported by others.
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ISSN:0002-9343
1555-7162
DOI:10.1016/0002-9343(62)90293-0