Tissue-resident memory T (T RM ) cells: Front-line workers of the immune system

Tissue-resident memory T (T ) cells play a vital role in local immune protection against infection and cancer. The location of T cells within peripheral tissues at sites of pathogen invasion allows for the rapid detection and elimination of microbes, making their generation an attractive goal for th...

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Bibliographic Details
Published inEuropean journal of immunology Vol. 53; no. 11; p. e2250060
Main Authors Osman, Maleika, Park, Simone L, Mackay, Laura K
Format Journal Article
LanguageEnglish
Published Germany Wiley Subscription Services, Inc 01.11.2023
Subjects
Adjuvants
CD8 antigen
Immune system
Immunological memory
mucosal vaccination
tissue-resident memory T cells
T cell memory
peripheral immunity
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Summary:Tissue-resident memory T (T ) cells play a vital role in local immune protection against infection and cancer. The location of T cells within peripheral tissues at sites of pathogen invasion allows for the rapid detection and elimination of microbes, making their generation an attractive goal for the development of next-generation vaccines. Here, we discuss differential requirements for CD8 T cell development across tissues with implications for establishing local prophylactic immunity, emphasizing the role of tissue-derived factors, local antigen, and adjuvants on T cell generation in the context of vaccination.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0014-2980
1521-4141
DOI:10.1002/eji.202250060