Interendothelial junctions: structure, signalling and functional roles

Endothelial cell—cell adhesive junctions are formed by transmembrane adhesive proteins linked to a complex cytoskeletal network. These structures are important not only for maintaining adhesion between endothelial cells and, as a consequence, for the control of vascular permeability, but also for in...

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Bibliographic Details
Published inCurrent opinion in cell biology Vol. 9; no. 5; pp. 674 - 682
Main Authors Lampugnani, Maria Grazia, Dejana, Elisabetta
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.10.1997
Subjects
Animals
Cell Adhesion
Endothelium - physiology
Endothelium - ultrastructure
Humans
Intercellular Junctions - physiology
Signal Transduction - physiology
ZO zonula occludens
VE vascular endothelial
PECAM platelet/endothelial cell adhesion molecule
AJ adherens junction
EGF epidermal growth factor
PTP protein tyrosine phosphatase
APC adenomatous polyposis coli
PDZ/DHR PSD-95, discs large, ZO-1/discs-large homology region
E epithelial
TJ tight junction
MAGUK membrane-associated guanylate kinase
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Summary:Endothelial cell—cell adhesive junctions are formed by transmembrane adhesive proteins linked to a complex cytoskeletal network. These structures are important not only for maintaining adhesion between endothelial cells and, as a consequence, for the control of vascular permeability, but also for intracellular signalling properties. The establishment of intercellular junctions might affect the endothelial functional phenotype by the downregulation or upregulation of endothelial-specific activities.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0955-0674
1879-0410
DOI:10.1016/S0955-0674(97)80121-4