A Genetic Polymorphism in the CYP1B1 Gene in Patients with Squamous Cell Carcinoma of the Esophagus: An Iranian Mashhad Cohort Study Recruited Over 10 Years

• Published in: Pharmacogenomics Vol. 19; no. 6; pp. 539 - 546
• Main Authors: Moghadam, Azam Rastgar, Mehramiz, Mehrane, Entezari, Malihe, Aboutalebi, Hamideh, Kohansal, Fatemeh, Dadjoo, Parisa, Fiuji, Hamid, Nasiri, Mohammadreza, Aledavood, Seyed Amir, Anvari, Kazem, Simab, Saeideh Ahmadi, Khorrami, Mohammad Sadegh, Moradi, Ali, Hassanian, Seyed Mahdi, Ferns, Gordon A, Sales, Soodabeh Shahid, Avan, Amir
• Format: Journal Article
• Language: English
• Published: England Future Medicine Ltd 01.04.2018
• Subjects: Biomarkers; Cardiovascular disease; Cell cycle; Cohort analysis; CYP1B1 gene; Cytochrome; Deoxyribonucleic acid; DNA; Environmental factors; Esophageal cancer; Esophagus; Estrogens; Gene polymorphism; Genes; Genetic diversity; Genomics; Genotype & phenotype; Health risk assessment; Liver cancer; Medical prognosis; Metabolism; Minority & ethnic groups; Polymorphism; Population studies; Prostate cancer; Squamous cell carcinoma; Statistical analysis; Studies; Xenobiotics; United States > US; cytochrome p450; esophagus squamous cell carcinoma
• ISSN: 1462-2416; 1744-8042; 1744-8042
• DOI: 10.2217/pgs-2018-0197

Esophageal cancer is the eighth most common cancer globally and the seventh most common cause of cancer-related deaths in men. Recent studies have shown that CYP450, family 1, subfamily B, polypeptide 1, which plays a role in the metabolism of xenobiotics, is associated with several cancers. Therefore, in the present study we investigated the association between a genetic variant, CYP1B1-rs1056836 gene, with the clinical characteristics of patients with squamous cell carcinoma of the esophagus (ESCC). In this study, 117 patients with ESCC and 208 healthy controls were recruited. DNA was extracted and genotyped using real-time PCR-based TaqMan. Kaplan-Meier curves were utilized to assess overall and progression-free survival. To evaluate the relationship between clinicopathological data, genotypic frequencies, disease prognosis and survival, Pearson's χ and t-test were used. Logistic regression was utilized to assess the association between the risk of ESCC and genotypes. The genotypic frequency for GG, GC and CC were 58.6, 29.8 and 11.5%, respectively, in the healthy subjects and 51.8, 36.14 and 12% in the ESCC group. An association between the GG genotype and stage of ESCC was found. Also, statistically significant results were not found for this variation and risk of ESCC. Our findings suggest a relationship between the CYP1B1-rs1056836 genetic polymorphism and clinical features of ESCC, supporting further studies in larger populations in different ethnic groups, taking into account potentially important environmental factors such as diet.