Purine metabolism in HIV-1 virus-infected T lymphocyte population

Purine nucleotide metabolism has been studied in T-lymphocyte population in healthy subjects and in AIDS bearing patients. Nucleotide content was determined by HPLC. The overall rate of purine nucleotide synthesis was measured following the incorporation of 14C-formate into the nucleotides of a T ce...

Full description

Saved in:
Bibliographic Details
Published inBiomedicine & pharmacotherapy Vol. 50; no. 10; pp. 505 - 509
Main Authors Carlucci, F, Tabucchi, A, Perrett, D, Pizzichini, M, Rosi, F, Pagani, R, Marinello, E
Format Journal Article
LanguageEnglish
Published France Elsevier SAS 1996
Subjects
Acquired Immunodeficiency Syndrome - metabolism
Adult
Chromatography, High Pressure Liquid
Female
HIV Infections - metabolism
HIV virus
HIV-1
Humans
Male
Middle Aged
purine nucleotides
Purine Nucleotides - metabolism
T lymphocytes
T-Lymphocytes - metabolism
T lymphocytes
PBS
A
GTP
AMP
G
AIDS
HIV virus
GMP
purine nucleotides
ADP
IMP
GDP
PBL
EC
HPLC
Online AccessGet full text

Cover

More Information
Summary:Purine nucleotide metabolism has been studied in T-lymphocyte population in healthy subjects and in AIDS bearing patients. Nucleotide content was determined by HPLC. The overall rate of purine nucleotide synthesis was measured following the incorporation of 14C-formate into the nucleotides of a T cell suspension. The authors discuss the results, which indicate interesting variations in nucleotide content and a lower nucleotide synthesis, determined by kinetic studies.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0753-3322
DOI:10.1016/S0753-3322(97)89283-9