Synthesis of some hydroxynaphthazarins and their cardioprotective effects under ischemia-reperfusion in vivo

A series of hydroxynaphthazarins has been synthesized. Some of them were found in in vivo experiments to be protectors of myocardium under ischemia-reperfusion and to reduce the infarction zone by 50% without any adverse effect. All compounds exhibit a moderate or small toxicity and are active in lo...

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Published inBioorganic & medicinal chemistry letters Vol. 8; no. 6; pp. 587 - 592
Main Authors Anufriey, Victor Ph, Novikov, Vyacheslav L., Maximov, Oleg B., Elyakov, George B., Levitsky, Dmitry O., Lebedev, Alexander V., Sadretdinov, Safa M., Shvilkin, Alexei V., Afonskaya, Natalya I., Ruda, Mikhail Ya, Cherpachenko, Nina M.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 17.03.1998
Subjects
Animals
Hydroxylation
Magnetic Resonance Spectroscopy
Male
Mass Spectrometry
Models, Chemical
Myocardial Infarction - prevention & control
Naphthoquinones - chemical synthesis
Naphthoquinones - pharmacology
Nitroglycerin - pharmacology
Rabbits
Vasodilator Agents - chemical synthesis
Vasodilator Agents - pharmacology
Verapamil - pharmacology
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Summary:A series of hydroxynaphthazarins has been synthesized. Some of them were found in in vivo experiments to be protectors of myocardium under ischemia-reperfusion and to reduce the infarction zone by 50% without any adverse effect. All compounds exhibit a moderate or small toxicity and are active in low doses. A series of hydroxynaphthazarins has been synthesized. Some of them were found in in vivo experiments to be protectors of myocardium under ischemia and reperfusion and to reduce the infarction zone by 50% without any adverse effect.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(98)00075-4