In Vivo Evaluation of the Antitumor and Immunogenic Properties of Silver and Sodium Dichloroacetate Combination against Melanoma

• Published in: Journal of nanomaterials Vol. 2020; no. 2020; pp. 1 - 8
• Main Authors: Zamora-Ávila, Diana Elisa, Hernández-Vidal, Gustavo, Kawas-Garza, Jorge Ramsy, Rodríguez-Padilla, Cristina, Santana-Krímskaya, Silvia Elena, Franco-Molina, Moisés Armides, Torres-Cavazos, Zaida, Moreno-Degollado, Gustavo
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2020; Hindawi; Hindawi Limited
• Subjects: Anticancer properties; Apoptosis; Cancer therapies; Cell death; Cell growth; Colorimetry; Deoxyribonucleic acid; DNA; Evaluation; Experiments; Flow cytometry; Formulations; Glucose; Laboratories; Melanoma; Metabolism; Mitochondria; Nanomaterials; Nanoparticles; Nitric oxide; Penicillin; Silver; Sodium; Software; Tumors; United States > US; Mexico

Our main focus was to evaluate the efficacy of silver and sodium dichloroacetate as dual-function agents to be used in melanoma treatment. This strategy is designed to increase the activity of these two compounds that affect DNA integrity and the mitochondria at different levels. Furthermore, we eva...