Dynamic global variation in resistance and hypervirulence of carbapenem-resistant Klebsiella pneumoniae between 2010 and 2023

•26,713 CRKP genomes with spatiotemporal metadata from 90 countries were selected for genomic analysis.•Global CRKP presented divergent trends in resistance and hypervirulence between before and during the COVID-19 pandemic.•Substantial interregional molecular heterogeneity existed.•Isolation of non...

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Published inThe Journal of infection Vol. 90; no. 6; p. 106493
Main Authors Feilong, Zhang, Wenting, Yang, Binghuai, Lu, Bin, Cao
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.06.2025
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Summary:•26,713 CRKP genomes with spatiotemporal metadata from 90 countries were selected for genomic analysis.•Global CRKP presented divergent trends in resistance and hypervirulence between before and during the COVID-19 pandemic.•Substantial interregional molecular heterogeneity existed.•Isolation of non-clinical CRKP underscored the importance of One Health-driven surveillance.
Bibliography:content type line 23
SourceType-Scholarly Journals-1
ObjectType-Correspondence-1
ISSN:0163-4453
1532-2742
1532-2742
DOI:10.1016/j.jinf.2025.106493