Association between AXIN1 gene polymorphisms and epithelial ovarian cancer in Chinese population

• Published in: Biomarkers in medicine Vol. 13; no. 6; pp. 445 - 455
• Main Authors: Zhang, Yan, Wang, Yanyun, Huang, Xingming, Li, Qin, Li, Kai, You, Di, Song, Yaping, Su, Min, Zhou, Bin, Wang, Wei
• Format: Journal Article
• Language: English
• Published: England Future Medicine Ltd 01.04.2019
• Subjects: Adolescent; Adult; Age; Aged; Alleles; Axin Protein - genetics; Axin1 gene; Biomarkers; Breast cancer; Carcinoma, Ovarian Epithelial - genetics; Carcinoma, Ovarian Epithelial - pathology; China; Deoxyribonucleic acid; DNA; Enzymes; Female; Gene polymorphism; Genes; Genomes; Genotype; Genotype & phenotype; Humans; Liver cancer; Medical prognosis; Middle Aged; Mutation; Ovarian cancer; Pathogenesis; Polymorphism; Polymorphism, Single Nucleotide; Population; Population studies; Restriction fragment length polymorphism; Single-nucleotide polymorphism; Standard deviation; Studies; Survival; Tumorigenesis; Tumors; Young Adult; China; PCR-RFLP; epithelial ovarian cancer; Wnt/β-catenin signaling pathway; single nucleotide polymorphisms; gene; morphisms
• ISSN: 1752-0363; 1752-0371
• DOI: 10.2217/bmm-2018-0306

The study was aimed to explore the association between gene polymorphism and epithelial ovarian cancer (EOC) susceptibility as well as prognosis. A total of 165 EOC cases and 327 healthy controls were recruited to participate in this study. In total three tag SNPs in gene were genotyped using PCR-restriction fragment length polymorphism. Significantly increased EOC risk was found associated with the A/C heterozygous genotype of rs12921862, the C allele and C/T genotype in the rs1805105 and the T/T genotype of rs370681. Meanwhile, Kaplan-Meier survival curves showed that patients with rs12921862 C/C genotype improved overall survival in the EOC group. Our results suggest that the gene may be related to susceptibility and overall survival in EOC.