The Potential of Sheep or Camel Milk Constituents to Contribute to Novel Dressings for Diabetic Wounds

• Published in: International journal of molecular sciences Vol. 24; no. 24; p. 17551
• Main Authors: Flis, Zuzanna, Szatkowski, Piotr, Pielichowska, Kinga, Molik, Edyta
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 16.12.2023
• Subjects: Amputation; Animal bites; Antidiabetics; Diabetes; Disease; Hydrogels; Insulin; Metabolism; Milk; Patients; Peptides; Sheep; Skin; Ulcers; Wound healing; bioactive natural products; diabetic wounds; infectious diseases; bioactive compounds; anti-inflammation; sheep milk; camel milk
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms242417551

Impaired wound healing is a complication of diabetes, which constitutes a serious problem in clinical practice. Currently, there is a high demand on the market for local treatment options for difficult-to-heal wounds caused by diabetes. The development of dressings that accelerate wound healing has recently been the subject of much research. Sheep and camel milk is gaining importance due to the content of many bioactive substances with health-promoting effects, such as insulin, LF, proline, or CLA. Sheep and camel milk proteins are a promising source of insulin, antidiabetic, and antihypertensive peptides. Numerous studies show that local administration of insulin has a significant impact on the healing of diabetic wounds. Sheep and camel milk, due to the highest LF content among ruminants, reduces autoimmune inflammatory processes and protects against bacterial and viral infections in the wound environment. Sheep’s milk has the highest content of proline and CLA, and their addition to a hydrogel dressing can help in the development of an effective dressing material. The production of hydrogel dressings containing sheep and camel milk, which are naturally rich in the bioactive substances presented in this review, may be a promising step in the market of specialized dressings for difficult-to-heal diabetic wounds.