Synthesis of Some New Heterocyclic Compounds Derived from 3-Formylchromones and Their Antimicrobial Evaluation

The synthesis and antimicrobial evaluation of a series of chromone-linked substituted heterocyclic derivatives is described. The condensation of 3-formylchromone with acetoacetamide under Knoevenagel–Cope reaction conditions was also explored, and the condensation with 4-hydroxy-6-methyl-2 H -pyran-...

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Published inChemistry of heterocyclic compounds (New York, N.Y. 1965) Vol. 49; no. 12; pp. 1723 - 1731
Main Authors Bari, A., Ali, S. S., Kadi, A., Hashmi, I. A., Ng, S. W.
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.03.2014
Springer Nature
Springer
Subjects
Chemistry
Chemistry and Materials Science
Chemistry, Organic
Heterocyclic compounds
Organic Chemistry
Pharmacy
Physical Sciences
Science & Technology
pyranopyrones
Knoevenagel–Cope reaction
urease inhibitory
3-formylchromone
antimicrobial activity
enzyme inhibitors
pharmacophore
ACTIVE METHYLENE
SERIES
INDUCTION
Knoevenagel-Cope reaction
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Summary:The synthesis and antimicrobial evaluation of a series of chromone-linked substituted heterocyclic derivatives is described. The condensation of 3-formylchromone with acetoacetamide under Knoevenagel–Cope reaction conditions was also explored, and the condensation with 4-hydroxy-6-methyl-2 H -pyran-2-one constitutes a facile route to pyranopyrone fused systems. Most of the compounds exhibit good antimicrobial properties.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-014-1424-4