Gas chromatographic analysis of short-chain fatty acids in the standardization of medicinal formulations based on bacterial substrates
Recent years have seen increasing use of formulations containing sets of compensatory metabolites in the form of short-chain fatty acids (SCFA), i.e., acetic, propionic, butyric, isobutyric, valeric, and isovaleric acids. This has led to the need to adapt existing analytical methods to monitor the p...
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| Published in | Pharmaceutical chemistry journal Vol. 44; no. 6; pp. 334 - 336 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Boston
Springer US
01.10.2010
Springer |
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| Abstract | Recent years have seen increasing use of formulations containing sets of compensatory metabolites in the form of short-chain fatty acids (SCFA), i.e., acetic, propionic, butyric, isobutyric, valeric, and isovaleric acids. This has led to the need to adapt existing analytical methods to monitor the presence of SCFA in probiotic formulations. The main task of the present study was to develop an assay for SCFA in formulations based on bacterial substrates. This was addressed using gas chromatography with flame ionization detection. |
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| AbstractList | Recent years have seen increasing use of formulations containing sets of compensatory metabolites in the form of short-chain fatty acids (SCFA), i.e., acetic, propionic, butyric, isobutyric, valeric, and isovaleric acids. This has led to the need to adapt existing analytical methods to monitor the presence of SCFA in probiotic formulations. The main task of the present study was to develop an assay for SCFA in formulations based on bacterial substrates. This was addressed using gas chromatography with flame ionization detection. Recent years have seen increasing use of formulations containing sets of compensatory metabolites in the form of short-chain fatty acids (SCFA), i.e., acetic, propionic, butyric, isobutyric, valeric, and isovaleric acids. This has led to the need to adapt existing analytical methods to monitor the presence of SCFA in probiotic formulations. The main task of the present study was to develop an assay for SCFA in formulations based on bacterial substrates. This was addressed using gas chromatography with flame ionization detection. Key words: GC (gas chromatography), probiotics, short-chain fatty acids. |
| Audience | Academic |
| Author | Ramenskaya, G. V. Sheveleva, M. A. |
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| CitedBy_id | crossref_primary_10_1016_j_anaerobe_2014_05_002 crossref_primary_10_1016_j_heliyon_2023_e13381 crossref_primary_10_1186_s40543_019_0184_2 crossref_primary_10_1002_jsfa_12582 crossref_primary_10_1080_10643389_2015_1073493 crossref_primary_10_1016_j_talanta_2017_01_010 crossref_primary_10_3389_fmicb_2018_02651 |
| Cites_doi | 10.1002/lite.200800010 10.1002/bmc.580 10.1093/clinchem/20.9.1235 |
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| References | M. D. Ardatskaya, Dissertation for Doctorate in Medical Sciences [in Russian], Moscow (2003). BrühlLMatthöusBLipid Technol.2008203606310.1002/lite.200800010 ShenderovBAMedical Microbial Ecology and Functional Nutrition1998MoscowGrant’ Press2848in Russian CollinDPMcCormickPGSchmidtMGJ. Clin. Chem.197420123512371:CAS:528:DyaE2cXlsVOrtbg%3D ZhaoGNymanMJönssonJ ÅkeBiomed. Chromatogr.200520867468210.1002/bmc.580 462_CR2 L Brühl (462_CR5) 2008; 20 DP Collin (462_CR3) 1974; 20 G Zhao (462_CR4) 2005; 20 BA Shenderov (462_CR1) 1998 |
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| SubjectTerms | Acids Bacteria Chromatography Fatty acids Gas chromatography Ionization Medicine Metabolites Organic Chemistry Pharmacology/Toxicology Pharmacy probiotics Saturated fatty acids Standardization |
| Title | Gas chromatographic analysis of short-chain fatty acids in the standardization of medicinal formulations based on bacterial substrates |
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