Gas chromatographic analysis of short-chain fatty acids in the standardization of medicinal formulations based on bacterial substrates

Recent years have seen increasing use of formulations containing sets of compensatory metabolites in the form of short-chain fatty acids (SCFA), i.e., acetic, propionic, butyric, isobutyric, valeric, and isovaleric acids. This has led to the need to adapt existing analytical methods to monitor the p...

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Bibliographic Details
Published inPharmaceutical chemistry journal Vol. 44; no. 6; pp. 334 - 336
Main Authors Sheveleva, M. A., Ramenskaya, G. V.
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.10.2010
Springer
Subjects
Acids
Bacteria
Chromatography
Fatty acids
Gas chromatography
Ionization
Medicine
Metabolites
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
probiotics
Saturated fatty acids
Standardization
GC (gas chromatography)
short-chain fatty acids
probiotics
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Summary:Recent years have seen increasing use of formulations containing sets of compensatory metabolites in the form of short-chain fatty acids (SCFA), i.e., acetic, propionic, butyric, isobutyric, valeric, and isovaleric acids. This has led to the need to adapt existing analytical methods to monitor the presence of SCFA in probiotic formulations. The main task of the present study was to develop an assay for SCFA in formulations based on bacterial substrates. This was addressed using gas chromatography with flame ionization detection.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-010-0462-1