Modifications in adrenal activity during hepatocarcinogenesis by N-2-fluorenylacetamide

During chemical hepatocarcinogenesis by N-2-fluorenylacetamide, the hormonal status of female Sprague Dawley rats is largely modified. Adrenals present a modified activity which is evidenced by an enlargement of glomerulosa and reticularis zones and a decrease of the fasciculata, while medulla remai...

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Bibliographic Details
Published inSteroids Vol. 35; no. 5; pp. 489 - 501
Main Authors Lafaurie, M., Aussel, C., Stora, C., Krebs, B.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.05.1980
Subjects
2-Acetylaminofluorene - pharmacology
Adrenal Glands - drug effects
Adrenal Glands - pathology
Adrenal Glands - physiology
Aldosterone - blood
Animals
Body Weight - drug effects
Estradiol - blood
Female
Liver Neoplasms, Experimental - chemically induced
Organ Size - drug effects
Rats
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Summary:During chemical hepatocarcinogenesis by N-2-fluorenylacetamide, the hormonal status of female Sprague Dawley rats is largely modified. Adrenals present a modified activity which is evidenced by an enlargement of glomerulosa and reticularis zones and a decrease of the fasciculata, while medulla remain unchanged. The level of aldosterone remain quite normal in N-2-fluorenylacetamide treated rats despite changes observed in the glomerulosa. The cortisol level was lowered in agreement with the decreased size of the fasciculata. The estradiol level was normal despite the reduced activity of the ovaries. The possibility of a participation of the reticularis zone in the regulation of the estradiol level is suggested. The possible protective action of the adrenals during hepatocarcinogenesis is discussed.
ISSN:0039-128X
1878-5867
DOI:10.1016/S0039-128X(80)80003-1