Dietary Selenium Deficiency or Excess Reduces Sperm Quality and Testicular mRNA Abundance of Nuclear Glutathione Peroxidase 4 in Rats

• Published in: The Journal of nutrition Vol. 147; no. 10; pp. 1947 - 1953
• Main Authors: Zhou, Ji-Chang, Zheng, Shijie, Mo, Junluan, Liang, Xiongshun, Xu, Yuanfei, Zhang, Huimin, Gong, Chunmei, Liu, Xiao-Li, Lei, Xin Gen
• Format: Journal Article
• Language: English
• Published: United States American Institute of Nutrition 01.10.2017
• Subjects: 8-Hydroxy-2'-Deoxyguanosine; Abundance; Animals; Body weight; Deficiency Diseases - blood; Deficiency Diseases - complications; Deficiency Diseases - metabolism; Deformation; Deoxyguanosine; Deoxyguanosine - analogs & derivatives; Deoxyguanosine - blood; Diet; Glutathione; Glutathione peroxidase; Glutathione Peroxidase - metabolism; Liver; Liver - metabolism; Male; mRNA; Nutrition Disorders - blood; Nutrition Disorders - complications; Nutrition Disorders - metabolism; Parameter sensitivity; Peroxidase; Phospholipid Hydroperoxide Glutathione Peroxidase; Quality; Rats; Rats, Sprague-Dawley; Ribonucleic acid; RNA; RNA, Messenger - metabolism; Rodents; Selenium; Selenium - blood; Selenium - deficiency; Selenium - metabolism; Selenoprotein P - metabolism; Semen; Sperm; Spermatozoa; Testes; Testis - metabolism; Vitamin deficiency; Weaning; glutathione peroxidase 4; transcript variant; dietary selenium; sperm quality; rodent; selenoprotein P

Glutathione peroxidase (GPX) 4 and selenoprotein P (SELENOP) are abundant, and several variants are expressed in the testis. We determined the effects of dietary selenium deficiency or excess on sperm quality and expressions of GPX4 and SELENOP variants in rat testis and liver. After weaning, male S...