Neuroendocrine carcinomas: Role of immunocytochemistry and electron microscopy

Neuroendocrine tumors occur in many sites of the body and can present significant diagnostic problems when poorly differentiated. To identify a tumor as neuroendocrine, pathologists commonly use either immunocytochemistry or electron microscopy. In this report, the various immunocytochemical reagent...

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Bibliographic Details
Published inHuman pathology Vol. 29; no. 12; pp. 1367 - 1371
Main Authors Hammond, Elizabeth H, Yowell, Robert L, Flinner, Robert L
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.12.1998
Subjects
Antibodies, Neoplasm - analysis
Biomarkers, Tumor - metabolism
Carcinoma, Neuroendocrine - diagnosis
Carcinoma, Neuroendocrine - metabolism
Carcinoma, Neuroendocrine - ultrastructure
Diagnosis, Differential
electron microscopy
Humans
immunocytochemistry
Immunohistochemistry - economics
Male
Microscopy, Electron - economics
Neoplasms - diagnosis
Neoplasms - metabolism
Neoplasms - ultrastructure
neuroendocrine carcinoma
APUD
NSE
GI
NCAM
neuroendocrine carcinoma
immunocytochemistry
electron microscopy
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Summary:Neuroendocrine tumors occur in many sites of the body and can present significant diagnostic problems when poorly differentiated. To identify a tumor as neuroendocrine, pathologists commonly use either immunocytochemistry or electron microscopy. In this report, the various immunocytochemical reagents are reviewed along with the ultrastructural features of neuroendocrine tumors. Site-specific variations in neuroendocrine tumors are discussed. A cost-effectiveness evaluation was performed on tumors from one laboratory which showed that electron microscopy was a less expensive diagnostic modality if more than three antibodies were necessary to arrive at the correct pathological diagnosis.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0046-8177
1532-8392
DOI:10.1016/S0046-8177(98)90004-1