Insulin-like growth factor I, insulin-like growth factor binding protein 3, and atrial fibrillation in the elderly

• Published in: The journals of gerontology. Series A, Biological sciences and medical sciences Vol. 69; no. 8; p. 1025
• Main Authors: Duron, Emmanuelle, Vidal, Jean-Sébastien, Funalot, Benoît, Brunel, Nadège, Viollet, Cécile, Seux, Marie-Laure, Treluyer, Jean-Marc, Epelbaum, Jacques, Bouc, Yves Le, Hanon, Olivier
• Format: Journal Article
• Language: English
• Published: United States 01.08.2014
• Subjects: Aged; Aged, 80 and over; Atrial Fibrillation - blood; Cross-Sectional Studies; Female; Humans; Insulin-Like Growth Factor Binding Protein 3 - blood; Insulin-Like Growth Factor I - analysis; Logistic Models; Male; Insulin-like growth factor-I; Insulin-like growth factor binding protein-3; Elderly participants; Atrial fibrillation
• ISSN: 1758-535X
• DOI: 10.1093/gerona/glt206

Insulin-like growth factor I (IGF-I) and insulin-like growth factor binding protein 3 (IGFBP-3) are involved in oxidative stress and atherosclerosis; however, the relationship between the IGF-I system and atrial fibrillation (AF) is not known. The objective of this analysis was to assess, the relationship between IGF-I and IGFBP-3 serum levels and AF among elderly participants. In this cross-sectional study, 719 participants (mean age [SD] years: 78.2 [6.8]; 31.8% men) were evaluated during an outpatient geriatric assessment. AF was determined by electrocardiogram or medical record. Participants were classified into two groups: Participants with AF (n = 91) or without AF (n = 628). IGF-I and IGFBP-3 serum levels were determined by enzyme linked immunosorbent assay. After adjusting for age and sex, the mean IGF-I and IGFBP-3 serum levels were significantly lower among AF participants than among non-AF participants (mean IGF-I ng/mL [SD] = 133.8 [66.6] vs 157.9 [80.0], p = .02; mean IGFBP-3 ng/mL [SD] = 3,653 [1,393] vs 4,151 [1,583], p = .03, respectively). After adjusting for confounding factors (age, gender, beta blocker medication, heart rate, hypertension, stroke, and chronic heart failure), low IGF-I serum level (OR [95% CI] = 0.66 [0.49-0.87]) and low IGFBP-3 serum level (0.71 [0.54-0.93]) remained independent determinants of AF. Low IGF-I and low IGFBP-3 serum levels were independently associated with AF in this elderly population. This result should be confirmed in a longitudinal study to evaluate whether IGF-I and/or IGFBP-3 serum levels are predictive of incident AF.