When to screen children with Down syndrome for celiac disease?

The coexistence of Down syndrome (DS) and celiac disease (CD) has been reported in many studies. In our study, we examined 82 children with DS aged 8 months to 8.6 years for the existence of CD using serological markers immunoglobulin A (IgA) and immunoglobulin G (IgG) transglutaminase antibodies, f...

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Bibliographic Details
Published inJournal of tropical pediatrics (1980) Vol. 56; no. 6; p. 443
Main Authors Pavlovic, Momcilo, Radlovic, Nedeljko, Lekovic, Zoran, Stojsic, Zorica, Puleva, Katja, Berenji, Karolina
Format Journal Article
LanguageEnglish
Published England 01.12.2010
Subjects
Autoantibodies - blood
Biomarkers - blood
Celiac Disease - blood
Celiac Disease - complications
Celiac Disease - diagnosis
Celiac Disease - epidemiology
Celiac Disease - immunology
Child
Child, Preschool
Down Syndrome - complications
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunoglobulin A - blood
Immunoglobulin G - blood
Infant
Male
Prevalence
Serbia - epidemiology
Transglutaminases - blood
Serbia
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Summary:The coexistence of Down syndrome (DS) and celiac disease (CD) has been reported in many studies. In our study, we examined 82 children with DS aged 8 months to 8.6 years for the existence of CD using serological markers immunoglobulin A (IgA) and immunoglobulin G (IgG) transglutaminase antibodies, followed by follow-up determination of total IgA levels. In four children who were positive for one of the above-mentioned antibodies, enteric biopsy has been performed that showed absence of CD. Our findings raise doubt about the need for obligatory serological screening of children with DS aged <8 years.
ISSN:1465-3664
DOI:10.1093/tropej/fmq026