HIV-1 Subtype A, D, G, AG and unclassified sequences identified in South Africa

HIV-1 subtype C accounts for the vast majority of infections in South Africa. However, increasingly non-C subtypes are being detected. Here we report 10 viruses that contain sequences that group with subtypes A, D, and G as well as CRF02_AG and 1 that could not be classified. Most of these individua...

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Published inAIDS research and human retroviruses Vol. 18; no. 9; p. 681
Main Authors Bredell, Helba, Hunt, Gillian, Casteling, Alison, Cilliers, Tonie, Rademeyer, Celia, Coetzer, Mia, Miller, Steven, Johnson, David, Tiemessen, Caroline T, Martin, Desmond J, Williamson, Carolyn, Morris, Lynn
Format Journal Article
LanguageEnglish
Published United States 10.06.2002
Subjects
HIV Infections - epidemiology
HIV Infections - virology
HIV-1 - classification
HIV-1 - genetics
Humans
Phylogeny
Recombination, Genetic
Sequence Analysis, RNA
South Africa - epidemiology
South Africa
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Summary:HIV-1 subtype C accounts for the vast majority of infections in South Africa. However, increasingly non-C subtypes are being detected. Here we report 10 viruses that contain sequences that group with subtypes A, D, and G as well as CRF02_AG and 1 that could not be classified. Most of these individuals were from other countries in Africa. Some of these sequences were in combination with subtype C, possibly indicating local recombination events. Although there is no indication of endemic spread of these viruses, continued monitoring is warranted to track genetic changes, which may impact on diagnostic testing, therapeutic responses to antiretroviral therapies, and vaccine design.
ISSN:0889-2229
1931-8405
DOI:10.1089/088922202760019400