Lysenin: A sphingomyelin specific pore-forming toxin

Sphingomyelin is a major sphingolipid in mammalian cells. Recent results indicate that sphingomyelin is a reservoir of lipid second messengers, ceramide and sphingosine-1-phosphate. Sphingomyelin is also a major component of sphingolipid and cholesterol-rich membrane domains (lipid rafts). Lysenin i...

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Published inBiochimica et biophysica acta Vol. 1780; no. 3; pp. 612 - 618
Main Authors Shogomori, Hidehiko, Kobayashi, Toshihide
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.03.2008
Subjects
Animals
Cholesterol
Cholesterol - metabolism
Glycolipids
Glycolipids - metabolism
Humans
Lipid domain
Lipid rafts
Membrane Microdomains - metabolism
Pore Forming Cytotoxic Proteins - metabolism
Sphingomyelins - metabolism
Toxins, Biological - metabolism
Lipid domain
Lipid rafts
Glycolipids
Cholesterol
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Summary:Sphingomyelin is a major sphingolipid in mammalian cells. Recent results indicate that sphingomyelin is a reservoir of lipid second messengers, ceramide and sphingosine-1-phosphate. Sphingomyelin is also a major component of sphingolipid and cholesterol-rich membrane domains (lipid rafts). Lysenin is a pore-forming toxin that specifically binds sphingomyelin. The binding of lysenin to sphingomyelin is dependent on the membrane distribution of the lipid, i.e. the toxin selectively binds sphingomyelin clusters. Development of a non-toxic lysenin mutant revealed the spatial and functional heterogeneity of sphingolipid-rich membrane domains.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:0304-4165
0006-3002
1872-8006
DOI:10.1016/j.bbagen.2007.09.001