Inhibition of Dunning tumor growth by melatonin
Injections of the pineal hormone melatonin reduced growth and increased doubling time of the R3327H Dunning prostatic adenocarcinoma in the Copenhagen X Fisher rat. This occurred even though testosterone levels (50% of normal) were ostensibly high enough to maintain normal tumor growth. Melatonin ma...
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| Published in | The Journal of urology Vol. 139; no. 5; p. 1099 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
United States
01.05.1988
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| Subjects | |
| Online Access | Get more information |
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| Abstract | Injections of the pineal hormone melatonin reduced growth and increased doubling time of the R3327H Dunning prostatic adenocarcinoma in the Copenhagen X Fisher rat. This occurred even though testosterone levels (50% of normal) were ostensibly high enough to maintain normal tumor growth. Melatonin may act directly upon the conversion of testosterone to dihydrotestosterone to inhibit tumor growth. Alternatively, a more complicated mechanism may be involved since studies on MCF breast cancer tissue indicate an estrogen requirement for inhibition of growth by melatonin. |
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| AbstractList | Injections of the pineal hormone melatonin reduced growth and increased doubling time of the R3327H Dunning prostatic adenocarcinoma in the Copenhagen X Fisher rat. This occurred even though testosterone levels (50% of normal) were ostensibly high enough to maintain normal tumor growth. Melatonin may act directly upon the conversion of testosterone to dihydrotestosterone to inhibit tumor growth. Alternatively, a more complicated mechanism may be involved since studies on MCF breast cancer tissue indicate an estrogen requirement for inhibition of growth by melatonin. |
| Author | Philo, R Berkowitz, A S |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/3283381$$D View this record in MEDLINE/PubMed |
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| Snippet | Injections of the pineal hormone melatonin reduced growth and increased doubling time of the R3327H Dunning prostatic adenocarcinoma in the Copenhagen X Fisher... |
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| SubjectTerms | Adenocarcinoma - drug therapy Animals Gonadotropin-Releasing Hormone - analysis Male Melatonin - therapeutic use Prostatic Neoplasms - drug therapy Rats Testosterone - blood |
| Title | Inhibition of Dunning tumor growth by melatonin |
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