Inhibition of Dunning tumor growth by melatonin
Injections of the pineal hormone melatonin reduced growth and increased doubling time of the R3327H Dunning prostatic adenocarcinoma in the Copenhagen X Fisher rat. This occurred even though testosterone levels (50% of normal) were ostensibly high enough to maintain normal tumor growth. Melatonin ma...
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Published in | The Journal of urology Vol. 139; no. 5; p. 1099 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
United States
01.05.1988
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Subjects | |
Online Access | Get more information |
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Summary: | Injections of the pineal hormone melatonin reduced growth and increased doubling time of the R3327H Dunning prostatic adenocarcinoma in the Copenhagen X Fisher rat. This occurred even though testosterone levels (50% of normal) were ostensibly high enough to maintain normal tumor growth. Melatonin may act directly upon the conversion of testosterone to dihydrotestosterone to inhibit tumor growth. Alternatively, a more complicated mechanism may be involved since studies on MCF breast cancer tissue indicate an estrogen requirement for inhibition of growth by melatonin. |
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ISSN: | 0022-5347 |
DOI: | 10.1016/S0022-5347(17)42795-9 |