Pulmonary complications following perfusion of the lungs
Conclusion and summary In order to evaluate some of the factors responsible for the post-perfusion lung complications, 98 dogs were divided into 14 groups; each group was perfused in a different manner. The various causes which could be implicated in the development of these lesions have been discus...
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| Published in | The Journal of thoracic and cardiovascular surgery Vol. 51; no. 6; pp. 767 - 776 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.06.1966
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| Subjects | |
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| Abstract | Conclusion and summary
In order to evaluate some of the factors responsible for the post-perfusion lung complications, 98 dogs were divided into 14 groups; each group was perfused in a different manner. The various causes which could be implicated in the development of these lesions have been discussed. It has become apparent that more than one factor plays a role in the production of this syndrome. The most important ones, however, seem to be the loss of surfactant, a non-physiologic pressure in the pulmonary vessels, sludging of the blood with slowing of the microcirculation, an impediment to the pulmonary venous return with elevation of the pulmonary capillary pressure, and denaturation of proteins.
More work is certainly needed in order to determine the importance of each factor and to devise means of prevention. |
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| AbstractList | Conclusion and summary
In order to evaluate some of the factors responsible for the post-perfusion lung complications, 98 dogs were divided into 14 groups; each group was perfused in a different manner. The various causes which could be implicated in the development of these lesions have been discussed. It has become apparent that more than one factor plays a role in the production of this syndrome. The most important ones, however, seem to be the loss of surfactant, a non-physiologic pressure in the pulmonary vessels, sludging of the blood with slowing of the microcirculation, an impediment to the pulmonary venous return with elevation of the pulmonary capillary pressure, and denaturation of proteins.
More work is certainly needed in order to determine the importance of each factor and to devise means of prevention. |
| Author | Lou, Wu Awad, John A. Lemieux, J.M. |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/5944100$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/S0022-5223(19)32891-0 10.1016/S0022-5223(19)33405-1 10.1016/S0022-5223(19)33254-4 10.1161/01.CIR.19.5.646 10.1113/expphysiol.1954.sp001047 10.1378/chest.48.3.269 10.1001/archsurg.1963.01310070128017 10.1097/00000658-196210000-00010 10.1016/S0039-6109(16)37233-4 10.1097/00000658-196310000-00015 10.1016/S0022-5223(19)33331-8 10.1016/S0022-5223(19)33184-8 10.1038/1751125b0 10.1097/00000658-196211000-00013 10.1016/S0033-0620(61)80015-7 10.1016/S0022-5223(19)33363-X 10.1016/S0039-6109(16)37532-6 10.1016/S0022-5223(19)33036-3 10.1093/ajcp/34.5.442 10.3181/00379727-95-23156 10.1016/S0039-6109(16)37531-4 |
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In order to evaluate some of the factors responsible for the post-perfusion lung complications, 98 dogs were divided into 14 groups;... |
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| SubjectTerms | Animals Chemotherapy, Cancer, Regional Perfusion - adverse effects Cyanosis - etiology Dogs Dyspnea - etiology Erythrocyte Aggregation - etiology Fever - etiology In Vitro Techniques Lung Mortality Protein Denaturation Pulmonary Alveoli - physiopathology Respiratory Insufficiency - etiology Surface Tension |
| Title | Pulmonary complications following perfusion of the lungs |
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