ε-Amino caproic acid additive decreases fibrin bandage performance in a swine arterial bleeding model

• Published in: Thrombosis research Vol. 108; no. 5; pp. 341 - 345
• Main Authors: Rothwell, Stephen W, Fudge, James M, Reid, Thomas J, Krishnamurti, Chitra
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Ltd 15.12.2002; Elsevier Science
• Subjects: Aminocaproic Acid - pharmacology; Animals; Arterial hemorrhage; Arteries - injuries; Biological and medical sciences; Blood Coagulation - drug effects; Blood Coagulation Tests; Blood Loss, Surgical - prevention & control; Blood. Blood coagulation. Reticuloendothelial system; Disease Models, Animal; Fibrin dressing; Fibrin Tissue Adhesive - chemistry; Fibrin Tissue Adhesive - standards; Fibrinogen; Hemorrhage - prevention & control; Hemorrhage - therapy; Hemostasis - drug effects; Hemostatic Techniques - standards; Hemostatics - pharmacology; Male; Medical sciences; Occlusive Dressings - standards; Pharmacology. Drug treatments; Swine; Wound Healing - drug effects; Arterial hemorrhage; TT; aPTT; PT; Swine; Fibrin dressing; Fibrinogen; T b; EACA; Animal model; Aminocaproic acid; Hemorrhage; Artery; Pig; Fibrin; Dressing; Vertebrata; Mammalia; Treatment; Technology; Animal; Artiodactyla; Ungulata
• ISSN: 0049-3848; 1879-2472
• DOI: 10.1016/S0049-3848(03)00111-7

ε-Amino caproic acid (EACA), a lysine analog that inhibits the activity of plasmin, was added to Nycomed (TC-S) fibrin bandages, and the bandages were tested for hemostatic efficacy in a swine femoral artery bleeding model. The blood loss using the bandage with EACA (TC-S+EACA; 728.8±132 g, n=5) was much greater as compared to the TC-S bandage alone (TC-S; 237.8±47.9 g, n=6, p=.02). The time to “cessation of bleeding” ( T b) was also increased for animals treated with TC-S+EACA bandages compared to the TC-S controls (33.6±10.8 min vs. 9.2±2.2 min; p=.05). Although plasma fibrinogen concentration decreased in animals treated with the TC-S+EACA bandage, activated partial thromboplastin times (aPTT) and thrombin times (TT) were decreased. Animals treated with the TC-S control bandage exhibited no changes in fibrinogen, aPTT or TT. Prothrombin times (PT) were unchanged in either group. In conclusion, addition of EACA to the Nycomed product decreased fibrin bandage efficiency.