Contraceptive efficacy of testosterone-estradiol implants in male rhesus monkeys

Rhesus monkeys (Macaca mulatta) were treated with testosterone (100μg/kg/day) plus estradiol (0.5μg/kg/day) via subcutaneous polydimethylsiloxane (PDS, Silastic) implants. This treatment caused a striking reversible sterility. No pregnancies were observed in females bred to the steroid-treated males...

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Bibliographic Details
Published inContraception (Stoneham) Vol. 27; no. 4; pp. 383 - 389
Main Authors Lobl, T.J., Kirton, K.T., Forbes, A.D., Ewing, L.L., Kemp, P.L., Desjardins, C.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.04.1983
Subjects
Animals
Blood Chemical Analysis
Contraceptive Agents, Male - administration & dosage
Delayed-Action Preparations
Drug Combinations
Estradiol - pharmacology
Fertility - drug effects
Macaca mulatta
Male
Semen - analysis
Spermatozoa - drug effects
Testosterone - pharmacology
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Summary:Rhesus monkeys (Macaca mulatta) were treated with testosterone (100μg/kg/day) plus estradiol (0.5μg/kg/day) via subcutaneous polydimethylsiloxane (PDS, Silastic) implants. This treatment caused a striking reversible sterility. No pregnancies were observed in females bred to the steroid-treated males. In contrast, there was no difference in pregnancy rate of females bred to control and steroid-treated monkeys for 14 weeks, beginning 17 weeks after removal of the steroid-filled implants.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0010-7824
1879-0518
DOI:10.1016/S0010-7824(83)80017-1