Morphometry in endocrine pathology

The most important purposes of morphometry in endocrine pathology are described. With the introduction of immunocytochemical techniques by Sternberger in 1969 a new field for detailed morphometric analysis in endocrine pathology was opened. The application of morphometry in combination with the immu...

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Bibliographic Details
Published inPathology, research and practice Vol. 179; no. 2; p. 220
Main Authors Oberholzer, M, Heitz, P U, Klöppel, G, Ehrsam, R E
Format Journal Article
LanguageEnglish
Published Germany 01.11.1984
Subjects
Duodenal Ulcer - etiology
Duodenal Ulcer - pathology
Duodenal Ulcer - physiopathology
Endocrine Glands - pathology
Female
Gastric Acid - secretion
Gastrins - secretion
Humans
Infant, Newborn
Male
Pancreas - pathology
Pregnancy
Pregnancy in Diabetics - pathology
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Summary:The most important purposes of morphometry in endocrine pathology are described. With the introduction of immunocytochemical techniques by Sternberger in 1969 a new field for detailed morphometric analysis in endocrine pathology was opened. The application of morphometry in combination with the immunocytochemical staining of cells is illustrated by studies of the role of gastrin and gastric secretion in the etiology of duodenal ulcer. For such studies morphologic alterations have to be quantified. Morphometry as an instrument for characterizing diseases has been used in various fields, e.g. to analyse nesidioblastosis, diabetes mellitus or papillary carcinomas of the thyroid gland.
ISSN:0344-0338
DOI:10.1016/S0344-0338(84)80133-8