Hyaluronic Acid-Conjugated Mesoporous Silica Nanoparticles Loaded with Dual Anticancer Agents for Chemophotodynamic Cancer Therapy

Present cancer treatments using chemotherapy are limited owing to both significant side effects to normal cells and high recurrence rates. In this study, we demonstrated cancer cell-targeting nanoparticles that load multiple anticancer agents for both specific treatments to cancer and substantial th...

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Published inJournal of nanomaterials Vol. 2019; no. 2019; pp. 1 - 11
Main Authors Key, Jaehong, Park, Kyeongsoon, Park, Hyungkyu, Jeong, Seokhyeon, Yi, Bong Gu, Park, Sanghyo
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2019
Hindawi
Hindawi Limited
Subjects
Acids
Anticancer properties
Cancer
Cancer therapies
Chemotherapy
Doxorubicin
Drug delivery systems
Drug resistance
Fluorescence
Free radicals
Hyaluronic acid
Nanomaterials
Nanoparticles
Nanotechnology
Photodynamic therapy
Proteins
Side effects
Silicon dioxide
Toxicity
United States > US
Texas
Japan
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Summary:Present cancer treatments using chemotherapy are limited owing to both significant side effects to normal cells and high recurrence rates. In this study, we demonstrated cancer cell-targeting nanoparticles that load multiple anticancer agents for both specific treatments to cancer and substantial therapeutic effects. For this purpose, hyaluronic acid (HA) was conjugated to mesoporous silica nanoparticles (MSNs) for specifically targeting cancer cells. Moreover, the prepared HA-MSNs exhibited high drug loading potential and sustained drug release. Compared to bare MSNs, the HA-MSNs were internalized at an approximately three times higher rate in squamous cell carcinoma 7 (SCC7) cells. To enhance the anticancer effects of chemotherapy and photodynamic therapy (PDT), doxorubicin (DOX) and chlorin e6 (Ce6) were loaded in HA-MSNs (DOX/Ce6/HA-MSNs); the product exhibited highly effective cytotoxicity on green fluorescent protein-expressing squamous cell carcinoma 7 (SCC7) compared to the corresponding free drugs and HA-MSNs with DOX or Ce6 alone. This study indicates that the application of DOX/Ce6/HA-MSNs in chemotherapy and PDT exerts significant therapeutic effects against SCC7.
ISSN:1687-4110
1687-4129
DOI:10.1155/2019/3481397