Biosynthesis of thromboxane by snake ( Elaphe obsoleta) erythrocytes and the requirement of eicosanoid production for blood clotting

Lower vertebrates provide important insights into the evolution of eicosanoid synthesis and function. Whole snake blood, purified nucleated erythrocytes, and isolated leukocytes activated by clotting or A23187 produced thromboxane, PGE 2, and 5-lipoxygenase products. Indomethacin's complete inh...

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Bibliographic Details
Published inBiochimica et biophysica acta Vol. 1334; no. 1; pp. 23 - 27
Main Authors Herman, Ceil A, Wang, Xinying, Gronert, Karsten
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 11.02.1997
Subjects
Animals
Arachidonate 5-Lipoxygenase - analysis
Blood Coagulation
Calcimycin
Clotting
Cyclooxygenase
Eicosanoids - biosynthesis
Elaphe obsoleta
Erythrocyte
Erythrocytes - metabolism
Leukocytes - metabolism
Lipoxygenase
Reptile
Snakes - blood
Thromboxanes - biosynthesis
Erythrocyte
Elaphe obsoleta
Cyclooxygenase
Reptile
Lipoxygenase
Clotting
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Summary:Lower vertebrates provide important insights into the evolution of eicosanoid synthesis and function. Whole snake blood, purified nucleated erythrocytes, and isolated leukocytes activated by clotting or A23187 produced thromboxane, PGE 2, and 5-lipoxygenase products. Indomethacin's complete inhibition of clotting suggests eicosanoids produced by these cells are important in snake blood hemostasis.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0304-4165
0006-3002
1872-8006
DOI:10.1016/S0304-4165(96)00122-5