A rapid screening test for deficiency of plasma ceruloplasmin and its value in the diagnosis of Wilson's disease

A spot test is described which makes it possible to determine simply and with a satisfactory degree of certainty whether or not an individual has more or less than about 20 mg. of ceruloplasmin per 100 ml. of plasma or serum. The test should be applicable as a screening procedure to detect asymptoma...

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Bibliographic Details
Published inThe American journal of medicine Vol. 28; no. 4; pp. 550 - 554
Main Authors Aisen, Philip, Schorr, Julian B., Morell, Anatol G., Gold, Ruth Z., Scheinberg, I.Herbert
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.04.1960
Subjects
Ceruloplasmin
Hepatolenticular Degeneration - blood
Humans
Old Medline
Serum Globulins
HEPATOLENTICULAR DEGENERATION/blood
SERUM GLOBULIN
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Summary:A spot test is described which makes it possible to determine simply and with a satisfactory degree of certainty whether or not an individual has more or less than about 20 mg. of ceruloplasmin per 100 ml. of plasma or serum. The test should be applicable as a screening procedure to detect asymptomatic children with hypoceruloplasminemia in whom Wilson's disease may subsequently develop. Based on current knowledge, and with available pharmacologic agents, it may be practicable to prevent or delay the onset of symptoms and signs of Wilson's disease in such children. The test may also be used in the study of patients suspected of having Wilson's disease.
Bibliography:ObjectType-Article-1
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ISSN:0002-9343
1555-7162
DOI:10.1016/0002-9343(60)90149-2