Porcine nephropathy induced by long-term ingestion of ochratoxin A

Nine pigs were fed crystalline ochratoxin A in their feed at a concentration of about 1 mg/kg. Three pigs and their controls were killed after 3 months and 6 pigs and controls were killed after 2 years. A decrease of the ratio TmPAH/CIn, increased urinary glucose excretion and decreased ability to c...

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Bibliographic Details
Published inVeterinary pathology Vol. 16; no. 4; p. 466
Main Authors Krogh, P, Elling, F, Friis, C, Hald, B, Larsen, A E, Lillehøj, E B, Madsen, A, Mortensen, H P, Rasmussen, F, Ravnskov, U
Format Journal Article
LanguageEnglish
Published United States 01.07.1979
Subjects
Animals
Creatinine - blood
Female
Kidney Diseases - chemically induced
Kidney Diseases - pathology
Kidney Diseases - veterinary
Ochratoxins - toxicity
Swine
Swine Diseases - chemically induced
Swine Diseases - pathology
Time Factors
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Summary:Nine pigs were fed crystalline ochratoxin A in their feed at a concentration of about 1 mg/kg. Three pigs and their controls were killed after 3 months and 6 pigs and controls were killed after 2 years. A decrease of the ratio TmPAH/CIn, increased urinary glucose excretion and decreased ability to concentrate urine, occurred within a few weeks and aggravated slightly during the 2-year period. Changes in renal structure, characterized by degeneration and atrophy of proximal tubules, interstitial fibrosis and hyalinization of glomeruli, were progressive during time of exposure, but terminal renal failure was not reached. The kidney, liver, muscular and adipose tissue contained 3 to 27 microgram ochratoxin A/kg after 3 months of exposure. No further accumulation of ochratoxin A residue was found after 2 years of exposure.
Bibliography:L74
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ISSN:0300-9858
1544-2217
DOI:10.1177/030098587901600410