Preparation of 6,6,1′,1′,6′,6′-hexadeutero sucrose
The preparation of 6,6,1′,1′,6′,6′-hexadeutero sucrose is reported. The synthesis is based on a triple oxidation of a protected sucrose 6,1′,6′-triol to the corresponding 6,1′,6′-tricarboxylic acid or ester, followed by reduction with lithium aluminium deuteride. This triple oxidation could be achie...
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Published in | Carbohydrate research Vol. 342; no. 15; pp. 2303 - 2308 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
OXFORD
Elsevier Ltd
05.11.2007
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | The preparation of 6,6,1′,1′,6′,6′-hexadeutero sucrose is reported. The synthesis is based on a triple oxidation of a protected sucrose 6,1′,6′-triol to the corresponding 6,1′,6′-tricarboxylic acid or ester, followed by reduction with lithium aluminium deuteride. This triple oxidation could be achieved either using cat. TEMPO–NaOCl (to the acid) or PDC–Ac
2O–
t-BuOH (to the
t-butyl carboxylic ester). |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0008-6215 1873-426X |
DOI: | 10.1016/j.carres.2007.06.024 |