Phagocytosis-stimulated macrophages. Production of prostaglandins and SRS-A, and prostaglandin effects on macrophage activation

Quiescent mouse peritoneal macrophages which phagocytose, and which respond to phagocytosis with a sudden elevation in hexose monophosphate shunt activity, immediately release into the medium oxygen metabolites, arachidonic acid oxygenation products, and lysosomal hydrolases. Such cells subsequently...

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Bibliographic Details
Published inImmunobiology (1979) Vol. 161; no. 3-4; p. 369
Main Authors Baggiolini, M, Schnyder, J, Dewald, B, Bretz, U, Payne, T G
Format Journal Article
LanguageEnglish
Published Netherlands 01.01.1982
Subjects
Animals
Arachidonic Acid
Arachidonic Acids - metabolism
Dinoprostone
Guinea Pigs
Hexosephosphates - metabolism
Hydrolases - metabolism
Lysosomes - enzymology
Macrophage Activation
Macrophages - metabolism
Mice
Phagocytosis
Prostaglandins - biosynthesis
Prostaglandins - pharmacology
Prostaglandins E - pharmacology
SRS-A - biosynthesis
Zymosan - pharmacology
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Summary:Quiescent mouse peritoneal macrophages which phagocytose, and which respond to phagocytosis with a sudden elevation in hexose monophosphate shunt activity, immediately release into the medium oxygen metabolites, arachidonic acid oxygenation products, and lysosomal hydrolases. Such cells subsequently differentiate and acquire the properties of inflammatory macrophages. The latter process appears to be under the control of prostaglandin E2 and possibly other cyclooxygenase products which are formed as a consequence of phagocytosis and seem to act as feed-back inhibitors.
ISSN:0171-2985
DOI:10.1016/S0171-2985(82)80094-6