Urinary glycosaminoglycan excretion as a laboratory marker in the diagnosis of interstitial cystitis

Urinary macromolecular uronate and glycosaminoglycan uronate concentrations were determined in 209 urine specimens obtained from 192 interstitial cystitis patients, 47 asymptomatic normal individuals and 32 spinal cord injury patients. As a group the concentration of macromolecular uronate or glycos...

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Bibliographic Details
Published inThe Journal of urology Vol. 149; no. 1; p. 31
Main Authors Hurst, R E, Parsons, C L, Roy, J B, Young, J L
Format Journal Article
LanguageEnglish
Published United States 01.01.1993
Subjects
Adult
Biomarkers
Cystitis - blood
Cystitis - diagnosis
Glycosaminoglycans - urine
Humans
Middle Aged
Odds Ratio
Regression Analysis
Sensitivity and Specificity
Uronic Acids - urine
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Summary:Urinary macromolecular uronate and glycosaminoglycan uronate concentrations were determined in 209 urine specimens obtained from 192 interstitial cystitis patients, 47 asymptomatic normal individuals and 32 spinal cord injury patients. As a group the concentration of macromolecular uronate or glycosaminoglycan uronate was significantly less in the interstitial cystitis patients than in the normal controls. Some interstitial cystitis patients showed low values of macromolecular uronate and glycosaminoglycan uronate. Analysis of the population distributions suggested that macromolecular uronate may have significant value in diagnosis of interstitial cystitis.
ISSN:0022-5347
1527-3792
DOI:10.1016/S0022-5347(17)35990-6