Impact of the first-line antiretroviral therapy on soluble markers of inflammation in cohort of human immunodeficiency virus type 1 in Moroccan patients: a prospective study

• Published in: Archives of microbiology Vol. 205; no. 6; p. 223
• Main Authors: Haddaji, Asmaa, Ouladlahsen, Ahd, Lkhider, Mustapha, Bensghir, Rajaa, Jebbar, Sanaa, Hilmi, Soufiane, Abbadi, Islam, Sodqi, Mustapha, Marih, Latifa, Pineau, Pascal, El Filali, Kamal Marhoum, Ezzikouri, Sayeh
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2023; Springer Nature B.V; Springer Verlag
• Subjects: Antiretroviral agents; Antiretroviral therapy; Biochemistry; Biomarkers; Biomedical and Life Sciences; Biotechnology; CD14 antigen; Cell Biology; Chronic infection; Drug therapy; Ecology; Enzyme-linked immunosorbent assay; HIV; HIV Infections - drug therapy; HIV-1; Human immunodeficiency virus; Humans; Immune response; Inflammation; Interleukin 6; Life Sciences; Lipopolysaccharide Receptors; Microbial Ecology; Microbiology; Microbiology and Parasitology; Original Paper; Prospective Studies; Tumor Necrosis Factor-alpha; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Virology; AIDS; sCD14; HIV; TNF-α; IL-6; Antiretroviral therapy
• ISSN: 0302-8933; 1432-072X
• DOI: 10.1007/s00203-023-03574-0

Chronic inflammation and immune activation are a hallmark of HIV-1 infection. In this study, we assessed inflammation biomarkers in a cohort of people living with HIV-1 (PLWH) before and after long-term suppressive combined antiretroviral therapy (cART). A single-center prospective cohort study was conducted to assess inflammatory biomarkers in 86 cART-naive PLWH and after receiving suppressive cART and 50 uninfected controls. Tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and soluble CD14 (sCD14) were measured using enzyme-linked immunosorbent assay (ELISA). No significant difference was found in IL-6 levels between cART-naïve PLWH and controls ( p  = 0.753). In contrast, TNF-α level showed a significant difference between cART naïve-PLWH and controls ( p  = 0.019). Interestingly, IL-6 and TNF-α levels were significantly decreased in PLWH after cART ( p  < 0.0001). The sCD14 showed no significant difference between cART-naïve patients and controls ( p  = 0.839) and similar levels were observed in pre- and post-treatment ( p  = 0.719). Our results highlight the critical importance of early treatment to reduce inflammation and its consequences during HIV infection.