Endogenous morphine

This review surveys the discovery of endogenous alkaloids in mammals. The formation of morphine in mammalian brain was assumed in 1970. The existence of morphine was demonstrated by radioimmunoassay. Identification of morphine was performed by spectroscopic methods. The isolation of mammalian morphi...

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Bibliographic Details
Published inPharmacological research Vol. 32; no. 1; pp. 15 - 20
Main Authors Hosztafi, Sándor, Fürst, Zsuzsanna
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.07.1995
Subjects
alcohol and formation of endogenous morphine
Alkaloids - analysis
Analgesics, Opioid - chemistry
Analgesics, Opioid - metabolism
endogenous opioids
Isoquinolines - metabolism
mammalian morphine
Morphinans - metabolism
Morphine - chemistry
Morphine - metabolism
morphine biosynthesis
Opioid Peptides - chemistry
Opioid Peptides - isolation & purification
Opioid Peptides - metabolism
Opioid Peptides - pharmacology
Opioid Peptides - physiology
Reticulin - metabolism
role of endogenous alkaloids
Thebaine - metabolism
mammalian morphine
endogenous opioids
morphine biosynthesis
role of endogenous alkaloids
alcohol and formation of endogenous morphine
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Summary:This review surveys the discovery of endogenous alkaloids in mammals. The formation of morphine in mammalian brain was assumed in 1970. The existence of morphine was demonstrated by radioimmunoassay. Identification of morphine was performed by spectroscopic methods. The isolation of mammalian morphine raises the question of biosynthesis. Recently, it has been shown that the biosynthetic pathway is similar to that that exists in poppy.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1043-6618
1096-1186
DOI:10.1016/S1043-6618(95)80003-4