Monoligated Pd(0)-catalyzed intramolecular ortho- and para-arylation of phenols for the synthesis of aporphine alkaloids. Synthesis of (−)-lirinine
An intramolecular palladium(0)-mediated ortho-arylation of phenols applied to the synthesis of various substituted aporphines is reported. Most significantly, the efficiency of the transformation was enhanced by the use of monoligated Pd(0) complexes. This methodology was extended to para-arylation...
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Published in | Tetrahedron Vol. 68; no. 6; pp. 1674 - 1681 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
OXFORD
Elsevier Ltd
11.02.2012
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | An intramolecular palladium(0)-mediated
ortho-arylation of phenols applied to the synthesis of various substituted aporphines is reported. Most significantly, the efficiency of the transformation was enhanced by the use of monoligated Pd(0) complexes. This methodology was extended to
para-arylation of phenols and employed in the synthesis of the aporphine alkaloid (−)-lirinine.
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0040-4020 1464-5416 |
DOI: | 10.1016/j.tet.2011.12.022 |