Absence of Trypanosoma cruzi myocardial infection reactivation in Chagas' heart transplant

The risk of Trypanosoma cruzi myocardial infection reactivation after immunosuppressive therapy has led to precluding heart transplantation as a therapeutic procedure for patients with end-stage Chagas' heart disease. We report a case of an orthotopic heart transplantation in a 43-year-old crit...

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Published inCardiovascular pathology Vol. 3; no. 4; pp. 257 - 259
Main Authors Bestetti, Reinaldo B., Castilho, Oswaldo T., Teno, Luiz A.C., Freitas, Olavo C.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.10.1994
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Summary:The risk of Trypanosoma cruzi myocardial infection reactivation after immunosuppressive therapy has led to precluding heart transplantation as a therapeutic procedure for patients with end-stage Chagas' heart disease. We report a case of an orthotopic heart transplantation in a 43-year-old critically ill chagasic patient with an uneventful postoperative period. He was treated with azathioprine and cyclosporine to control graft rejection and showed no reactivation of the chagasic infection. One year following surgery, the patient is doing well. Nonsteroidal therapy appears not to reactivate T. cruzi infection in transplant chagasic patients.
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ISSN:1054-8807
1879-1336
DOI:10.1016/1054-8807(94)90011-6